The game also shows only one dog rescuing the puppies from the DeVil manor. However, they do so while on their bicycles, which was a detail exclusively from this movie. They end up colliding simultaneously in the pond, as they did in the animated movie. Also in the game, Roger and Anita meet in the park while taking their dogs for a walk. She did not work for Cruella, and knew her only as an old schoolmate.

In the animated movie, Roger was a songwriter, and Anita's job was never mentioned. However, Roger and Anita have the same jobs as in the live-action movie: Roger's a video game designer, and Anita works for Cruella as a clothing designer, which gave Cruella the nasty idea for a genuine Dalmatian coat. In the game, most details follow the animated version of the movie.

The Disney computer game Disney's Animated Storybook: 101 Dalmatians (1997), which takes the user through the story in interactive ways, has a mixture of story elements from both of the animated One Hundred and One Dalmatians (1961) and the live-action movie.